Edward Carl Schwalbe

Dr Ed Schwalbe

Associate Professor

Department: Applied Sciences

Ed Schwalbe Staffprofile Northumbriauniversity255

Ed began his career with a BSc in Genetics from Leicester University. After working for several years in research labs focussed on medical and human genetics, Ed completed a Master's degree in Bioinformatics, again at Leicester University. After becoming interested in the analysis of large biological datasets during this course, he subsequently moved to Newcastle University to study for a PhD in cancer genomics in Professor Steve Clifford's lab, where his project investigated the molecular sub-classification of the childhood brain tumour, medulloblastoma, using genetic and epigenetic techniques.

After finishing the PhD, he continued working at Newcastle University as a postdoc, where his primary research role involved the continuation of work that arising from his PhD and undertaking collaborative research with investigators based at Bonn University and Malawi.

In October 2013, Ed moved to Northumbria as a Senior Lecturer in Bioinformatics and Biostatistics. Since then, he has continued to investigate childhood cancers, aiming at helping translate biological insights into clinically meaningful tests, and has extensive experience in the analysis of complex biological datasets.

Campus Address

Northumberland Building 447

Email Ed

Key Publications

Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study, Schwalbe, E., Lindsey, J., Danilenko, M., Hill, R., Crosier, S., Ryan, S., Williamson, D., Castle, J., Hicks, D., Kool, M., Milde, T., Korshunov, A., Pfister, S., Bailey, S., Clifford, S. 8 Oct 2024, In: Neuro-Oncology
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study, Schwalbe, E., Lindsey, J., Nakjang, S., Crosier, S., Smith, A., Hicks, D., Rafiee, G., Hill, R., Iliasova, A., Stone, T., Pizer, B., Michalski, A., Joshi, A., Wharton, S., Jacques, T., Bailey, S., Williamson, D., Clifford, S. Jul 2017, In: The Lancet Oncology
Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes, Sharma, T., Schwalbe, E., Williamson, D., Sill, M., Hovestadt, V., Mynarek, M., Rutkowski, S., Robinson, G., Gajjar, A., Cavalli, F., Ramaswamy, V., Taylor, M., Lindsey, J., Hill, R., Jäger, N., Korshunov, A., Hicks, D., Bailey, S., Kool, M., Chavez, L., Northcott, P., Pfister, S., Clifford, S. 1 Aug 2019, In: Acta Neuropathologica
Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study, Hill, R., Richardson, S., Schwalbe, E., Hicks, D., Lindsey, J., Crosier, S., Rafiee, G., Grabovska, Y., Wharton, S., Jacques, T., Michalski, A., Joshi, A., Pizer, B., Williamson, D., Bailey, S., Clifford, S. 1 Dec 2020, In: The Lancet Child and Adolescent Health
Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development, Williamson, D., Schwalbe, E., Hicks, D., Aldinger, K., Lindsey, J., Crosier, S., Richardson, S., Goddard, J., Hill, R., Castle, J., Grabovska, Y., Hacking, J., Pizer, B., Wharton, S., Jacques, T., Joshi, A., Bailey, S., Clifford, S. 2 Aug 2022, In: Cell Reports
Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma, Danilenko, M., Clifford, S., Schwalbe, E. 1 Dec 2021, In: Pharmacology and Therapeutics
Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development, Danilenko, M., Zaka, M., Keeling, C., Crosier, S., Lyman, S., Finetti, M., Williamson, D., Hussain, R., Coxhead, J., Zhou, P., Hill, R., Hicks, D., Rand, V., Joshi, A., Schwalbe, E., Bailey, S., Clifford, S. 1 Sep 2022, In: Acta Neuropathologica
Integration of genome-level data to allow identification of subtype-specific vulnerability genes as novel therapeutic targets, Schwalbe, E., H, L., Lafta, F., Barrow, T., Strathdee, G. 19 Aug 2021, In: Oncogene
Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity, Grabovska, Y., Mackay, A., O’Hare, P., Crosier, S., Finetti, M., Schwalbe, E., Pickles, J., Fairchild, A., Avery, A., Cockle, J., Hill, R., Lindsey, J., Hicks, D., Kristiansen, M., Chalker, J., Anderson, J., Hargrave, D., Jacques, T., Straathof, K., Bailey, S., Jones, C., Clifford, S., Williamson, D. 1 Dec 2020, In: Nature Communications

Current and Recent Projects

The role of maternal folate in childhood leukemia initiation; understanding the molecular mechanisms, McKay, J. (Principal Investigator), Schwalbe, E. (Co Investigator), World Cancer Research Fund International, 01/04/23 - 31/03/27, £346,625.00

PGR Supervision

Valentina Perrone The application of the Dental Cementum in Forensic Anthropology. An investigation of cementochronology for age estimation and life-history reconstruction in adults. Start Date: 31/01/2024 End Date: 25/10/2024
Zeloso Tiago A Taphonomic Atlas of Human Decomposition Patterns from Post-mortem Computed Tomography Start Date: 31/01/2024
Alice Iliasova Investigation of the molecular and clinical heterogeneity of medulloblastoma subgroups Start Date: 01/10/2014 End Date: 15/07/2022
Dean Thompson Transforming cancer molecular diagnostics: Molecular subgrouping of medulloblastoma via low-depth whole genome bisulfite sequencing Start Date: 01/10/2018 End Date: 10/09/2022
Sai Anugna Sureddi AI-Based Integration of Histopathological Images and Multi-omic Data for Improved Risk-Stratification in Medulloblastoma. Start Date: 01/10/2023

Qualifications

Biological Sciences PhD January 14 2012
Information not provided British Association for Cancer Research (BACR) 2013

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